Il Leone Mastrantonio is an Italian restaurant on the corner of Prestwich and Cobern Street in Green Point, Cape Town. Founded in 1996 by Gianni Mariano and Paolo Scalla, it brings family recipes and Italian culinary traditions to the table. The kitchen focuses on balancing flavors and honoring ingredients, with dishes that reflect the founders' heritage.

The restaurant is part of the Mastrantonio brand, which emphasizes craftsmanship in food service. The dining room is set in a corner building, with a straightforward approach to Italian meals. The menu avoids overcomplication, sticking to classic preparations.

Il Leone Mastrantonio operates from Tuesday to Sunday, serving lunch and dinner. The location in Green Point places it within walking distance of the neighborhood's residential and commercial areas. The restaurant has maintained its approach for over twenty-five years, with a focus on consistency rather than trend-chasing.